What Drugs Should Not Be Taken with CBD?

Hemp-derived CBD has gained notoriety for its ample range of medicinal uses and no side effects. But does the lack of significant side effects mean CBD is entirely safe when taken with other medications?

The Cytochrome P450 System

In order to understand how CBD may interact with other substances in your system, you must first understand what the cytochrome P450 system is and the role it plays.

The cytochrome P450 system, found within the liver, consists of enzymes that process and eliminate potentially toxic compounds. The P450 enzyme system is responsible for metabolizing over 60% of all pharmaceuticals.

Can CBD Oil Interact with Medications I’m Taking?

Research shows that CBD may interfere with the P450 system’s ability to metabolize other drugs. When you consume CBD, it inhibits the system’s ability to metabolize compounds found in pharmaceutical drugs meaning drugs can stay in your system longer. This can pose several risks especially if you are taking powerful painkillers like oxycodone and fentanyl.

CBD Oil and Blood Thinners

If you are taking CBD, you should pay particular attention to blood thinner medications like warfarin. Mixing CBD with blood thinners can make the blood thinner stay in your system for too long without being broken down, increasing the risk of potentially harmful side effects.

CBD and Adderall interaction

Adderall is commonly prescribed for conditions like narcolepsy, attention deficit disorder (ADD) and attention deficit hyperactivity disorder (ADHD). The unregulated use of Adderall is also common among college students, who find Adderall helpful in improving their ability to concentrate and overall productivity. However, Adderall has side effects like fatigue, depression, and anxiety, especially as the effects of the drug begin to wear off.

Due to its calming effects, CBD can reduce the effects of Adderall, creating a more balanced feeling if the effects of the drug are too strong. However, using CBD during the comedown may cause excessive fatigue and feelings of relaxation.

CBD Interactions with Other Drugs

Any drug that is metabolized by Cytochrome P450 System enzymes CYP3A4 or CYP2C19 is likely to interact with CBD.

These drugs include:

  • Warfarin/Coumadin
  • Steroids
  • HMG CoA reductase inhibitors
  • Prokinetics
  • HIV antivirals
  • Immune modulators
  • Antibiotics
  • Beta-blockers
  • PPIs
  • NSAIDs
  • Angiotensin II blockers
  • Oral hypoglycemic agents
  • Sulfonylureas

How to Dose CBD

One major factor determining how CBD may interact with other medications in your system is the potency of your daily dose. Stronger doses of CBD may stay in your body longer, thus interacting with the cytochrome P450 system for longer, as well. To ensure you are not taking a stronger dose than needed, start your CBD regimen with a relatively small dose and work your up slowly until you achieve the desired results.

Seek Professional Advice

For the most effective and safest CBD consumption practices, use pharmacist formulated CBD from a trusted CBD manufacturer and consult with your physician if you are taking any other medications. Using high-quality CBD with professional guidance will help you make the most of your CBD routine.

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